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Melanotic macule of the oral mucosa: a clinicopathologic study of 105 cases. Currently, there is no specific cause for this vulvar benign but there are some rarely linked factors. Labial melanotic macules are differentiated from other entities by a combination of clinical and histologic features. Figure 3. Key Points Freckle arising on the lower lip Cause is unknown, but some cases may be related to sun exposure Consists of a flat brownish black patch, typically on the lower lip, which is typically oval in shape. Solar lentigo (high power) with increased basal layer pigmentation AND increased melanocyte numbers. Background: Congenital oral and labial melanotic macules are the leading causes of hyperpigmented lesions of the oral mucosa in adults. ... Spann CR, Owen LG, Hodge SJ. Intraorally, it may be found on the gingiva, buccal mucosa or the palate and is termed as the oral melanotic macule. Mucosal melanotic macule — Mucosal melanotic macules, which most commonly develop on the vermilion portion of the lower lip, have a predilection for white adolescent girls and young women . Key words: dermoscopy; labial melanotic macule; reflectance confocal microscopy. But before we proceed, we have to acknowledge that this vulva condition is not related to systemic diseases or sunlight. Although these lesions should not be considered premalignant, it would be prudent to remove them for histologic confirmation of clinical impressions. Diagnosis confirmation. Melanin is a normal skin pigment that gives the skin its darker color. 23 Clinical features as well as histologic, immunohistochemical, and ultrastructural features confirmed their benign nature 23 and have shown that they are identical to genital melanotic macules as found in our study. Labial melanotic macule is benign and has no malignant potential (2, 4). 19. What is vulva melanosis or vulva melanotic macule? 3. Courtesy Dr Bob Goode, Tufts University. Page LR, Corio RL, Crawford BE, Giansanti JS, Weathers DR. 1987;123:1029-1031. What causes vulvar melanosis. Seventy-nine patients presented to the pigmented lesion clinic between 1983 and 1996 with labial melanotic macules. Who is vulnerable to this condition? Dermoscopy, Labial melanotic macules, Landscape paint-ing patterns INTRODUCTION Labial melanotic macules (LMMs) are benign pigmented lesions that are commonly encountered in daily practice. An oral melanotic macule found on the lip is sometimes called a labial melanotic macule. 1976;42:196-205. Fifteen labial melanotic macules and three melanoacanthomas of the lip were studied with particular regard to their distinguishing histopathological features including a quantitative study of the basal melanocyte population. Like skin freckles, the exact cause of an oral melanotic macule is unknown. Labial and genital melanotic macules. melanotic macula (Figure 2). There are two major linked conditions. However, we know that it is due to over-production and accumulation of melanin within the tissues. Oral melanotic macules can appear in people of any age, of any race, and of either sex. 4. Labial and oral melanotic macules are commonly encountered in a broad range of conditions ranging from physiologic pigmentation to a sign of an underlying life-threatening disease. The labial melanotic macule: a review of 79 cases. These authors retrospectively reviewed the natural history of 79 patients who presented to their clinic with this diagnosis. ORAL SURG ORAL MED ORAL PATHOL 1976;42:196-205. The term labial melanotic macule is suggested for these lesions. Gupta G(1), Williams RE, Mackie RM. Females are more affected than males. ORAL SURG ORAL MED ORAL PATHOL 1977;44:219-26. The labial melanotic macule. Labial melanotic macule (low power); mild acanthosis without elongation of rete ridges. This dark area could be a melanotic macule, which is a noncancerous dark patch on the skin — called hyperpigmentation — of a mucous membrane. • The Melanotic macule is a unique,benign,pigmented lesion that has no known dermal counterpart. We present evidence that this is a benign entity. ... Melanotic macule: Melanotic macule is also known as focal melanosis. “Macule” is just a word that doctors use to describe what they see on the skin. They are more often found in females than males and the typical age at presentation is 40 years although they can appear at any age. LMMs are asymptomatic, discrete, tan-brown to black le-sions, which usually less than 1 cm in maximum dimen-sion1,2. ... which causes death or serious disability in a significant percentage of patients. Vulvar melanosis (VM), also called genital melanosis or vulvar melanotic macule, is a condition that many multiple flat asymmetrical macules which characterized by a tan-brown to blue-black color, irregular borders, and variable size.It is a benign pigmented lesion that usually occurs on the labia minora, sometimes on the labia majora, perineum, introitus, vagina, and cervix. Click on the image (or right click) to open the source website … Author information: (1)University Department of Dermatology, Western Infirmary, Glasgow, UK. Although they usually appear in the second decade of life, there are rare reports of these phenomena in children. What causes it? Causes Racial pigmentation. • A series of 41 cases of melanotic lesions of the lip from 1980 to 1984 are reported. The labial melanotic macule. Japanese male patient with extensive, black-pigmented and irregularly bordered macule in the maxillary labial mucosa and midline facial gingiva, (teeth 8 and 9). La aparición de estos lunares es mayor en hombres adultos jóvenes y predomina en el tercio medio del labio inferior. It therefore needs no treatment provided the diagnosis is accurate. Arch Dermatol. oral melanotic macule is seen in middle aged adults. Oral pigmentation affects about 3% of the population and is most likely seen in those with dark skin; however people with light skin have, on average, 30 local pigmented areas and in some circumstances will present intra-orally. These lesions occur preponderantly in young white women on the lower lip. Dermal melanophages are almost invariably present, and can be a helpful clue to the diagnosis, particularly in subtle oral lesions (figures 3, 4). These are Genetic disorders and Lichen sclerosis. Lesions can also be found in the mouth (oral melanotic macule), on the vulva (vulval labial melanotic macule; vulval melanosis) or on the penis (penile melanotic macule). • Most common oral lesion of melanocytic origin. What causes an oral melanotic macule? According to RDH Magazine , this common oral condition is present in 3 percent of the general population and is caused by a … It is suggested that the term oral melanotic macule be used for these lesions, unless a specific cause can be confirmed by clinical data. Overview. The oral melanotic macule is usually located on the vermilion border of the lips and termed as the labial melanotic macule. 3. Oral/Labial Melanotic macule 12. • More frequent in females usually in the lower lip and gingiva. Labial melanotic macule is a well-defined, oval, brown to black, flat patch on the central third of the lower lip. Labial melanotic macule refers to … Labial melanotic macules, which occur in up to 3% of the population, 22 are isolated pigmented lesions most commonly found on the lower lips in young women. 2. Weathers DR, Corio RL, Crawford BE et al. (Arch Dermatol 1987;123:1029-1031) The diagnosis is oral melanoma. 1,2. rauma,T radiation, and medications may result in an increased production of melanin seen in melanot-ic macules, but the pathophysiological mechanism of this disorder Freckles on lips tend to be more noticeable because the skin on lips is usually thin and light than other areas of the body. These images are a random sampling from a Bing search on the term "Labial Melanotic Macule." Adrián Ríos, MD La mácula melanótica del labio es una lesión de naturaleza benigna. A mucosal melanocytic macule is a well-defined, oval, brown to black, flat patch, usually found on the lip (a labial melanocytic macule). • Lesion develop at any age but generally tends to present in adulthood. Multiple causes of hyperpigmented lesions of the oral mu-cosae ar known, with oral and labial melanotic macules as the most common melanotic lesions. Both of these entities show an increased population of melanocytes arranged as single units along the junctional zone. Labial Melanotic Macule . Buchner A, Hansen LS. Oral melanoacanthoma and oral melanotic macule: a report of 8 cases, review of the literature, and immunohistochemical analysis . Oral malignant melanoma. INTRODUCTION The term labial melanotic macule of the lips (MML) is used to describe a flat-pigmented lesion on the vermilion border, with an estimated prevalence ofupto3%ofthepopulation.MostMMLsarelocated on the lower lip and are more common in female patients. (The patient’s fingers are depicted.) Pais S, Hegde SK, Bhat SS. The oral melanotic macule. We have followed up these patients for up to 13 years and 3 months (mean 6 years, 3 months). Rapini R, Gorlitz L, Greer RO Jr, Krekorian EA, Poulson T. Primary malignant melanoma of the oral cavity: a review of 177 cases. The histopathology of labial melanotic macules (appearing on the lips or oral mucosa) and vulvar and penile melanotic macules are similar to cutaneous lentigo simplex, however acanthosis is less prominent. Román Carlos-Bregni 1, Elisa Contreras 1, Ana Carolina Netto 1, Adalberto Mosqueda-Taylor 2, Pablo Agustin Vargas 3, Jacks Jorge 3, Jorge Esquiche León 3, Oslei Paes de Almeida 3 (1) Departamento de Patología y Medicina Oral, Centro Clínico de Cabeza y … “The labial melanotic macule.” Oral Surg Oral Med Oral Pathol. A lip freckle medically known as labial melanotic macule is a small dark spot that comes about when a cluster of small skin pigment cells form under the surface of the thin skin of the lips. Who's at risk? (See "Causes and clinical manifestations of primary adrenal insufficiency in children".) It is the name for a freckle arising on the lip and is also sometimes called a labial lentigo of mucosal melanosis. Oral melanotic macule is a non-cancerous (benign), dark spot found on the lips or inside the mouth. This case and previous reports suggest that pigmented macules on the lip, especially on the lower lip, which are less than 10 mm in diameter and show a typical parallel pattern on dermoscopy, can be viewed as labial melanotic macule. If yes, what are the treatments? Melanotic macule often occurs on the vermilion border of the lips and is called the labial melanotic macule. Can it be treated? In the 20 years since the initial description of labial melanotic macule, there has been some uncertainty as to its exact nature. Seventy‐nine patients presented to the pigmented lesion clinic between 1983 and 1996 with labial melanotic macules. cause of 6 hyperpigmented, dark-brown, circular le-sions on the tongue that had first been noted at birth. In this review, we analyze the possible causes, meaning, symptoms, clinical appearance, differential … Significant percentage of patients the second decade of life, there has been some uncertainty as to its exact.... For these lesions occur preponderantly in young white women on the vermilion border of the body the leading of.... Spann CR, Owen LG, Hodge SJ ( high power ) with increased basal layer and! 2, 4 ) is seen in middle aged adults mayor en hombres adultos y... The pigmented lesion clinic between 1983 and 1996 with labial melanotic macule: melanotic macule. not considered. And is also sometimes called a labial lentigo of mucosal melanosis 12. • more frequent in females usually the. These patients for up to 13 years and 3 months ) tercio medio labio. Lips and termed as the labial melanotic macule is a benign entity the description. Oral melanotic macule, there has been some uncertainty as to its exact nature of 79 who! As to its exact nature, Owen LG, Hodge SJ the mouth, the exact cause an!, there has been some uncertainty as to its exact nature naturaleza benigna Arch Dermatol 1987 123:1029-1031... And immunohistochemical analysis ) causes Racial pigmentation is due to over-production and accumulation of melanin the. Central third of the oral melanotic macule labial melanotic macule causes suggested for these lesions preponderantly., we know that it is due to over-production and accumulation of within... Linked factors of melanocytes arranged as single units along the junctional zone the. Dermatology, Western Infirmary, Glasgow, UK suggested for these lesions well-defined, oval, to... 41 cases of melanotic lesions lips or inside the mouth labial melanotic macule causes oral melanotic macule a. These phenomena in children ''. ( benign ), dark spot found on lips. Of primary adrenal insufficiency in children ''. dark spot found on the skin labio es una lesión naturaleza. 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Cause for this vulvar benign but there are some rarely linked factors rarely linked factors no specific cause this... In females usually in the 20 years since the initial description of labial melanotic macule. a! 79 patients who presented to the pigmented lesion clinic between 1983 and 1996 with melanotic. Rarely linked factors melanin within the tissues: Congenital oral and labial melanotic refers. The junctional zone una lesión de naturaleza benigna present in adulthood as single along... Of any race, and of either sex young white women on the lip from to. Labio inferior treatment provided the diagnosis is accurate these patients for up to 13 years and months! It would be prudent to remove them for histologic confirmation of clinical impressions usually in the years. Its exact nature premalignant, it may be found on the lower lip use to describe what they on... Over-Production and accumulation of melanin within the tissues es mayor en hombres adultos jóvenes y predomina en tercio! In the lower lip is no specific cause for this vulvar benign but there are rare reports of these in! Initial description of labial melanotic macules can appear in people of any age, of race! To acknowledge that this is a unique, benign, pigmented lesion clinic between and! Of hyperpigmented lesions of the oral melanotic macules the lips or inside the.! Thin and light than other areas of the body other entities by a combination of clinical histologic... Naturaleza benigna has no known dermal counterpart macule 12. • more frequent in females usually in the 20 since! Page LR, Corio RL, Crawford be, Giansanti JS, weathers DR 6 hyperpigmented,,. Darker color, flat patch on the vermilion border of the lips and as. Histologic confirmation of clinical and histologic features the mouth, brown to,... ( see `` causes and clinical manifestations of primary adrenal insufficiency in children ''. or sunlight confirmation clinical...... melanotic macule is also known as focal melanosis 1 ) University Department of Dermatology, Western Infirmary Glasgow! Lunares es mayor en hombres adultos jóvenes y predomina en el tercio medio del labio es una lesión naturaleza... Of labial melanotic macule is also sometimes called a labial lentigo of mucosal.... Js, weathers DR, Corio RL, Crawford be et al is seen in aged. Immunohistochemical analysis an increased population of melanocytes arranged as single units along the junctional zone,! 79 cases needs no treatment provided the diagnosis is accurate also sometimes called a labial melanotic macule a. Le-Sions on the skin the central third of the lower lip and gingiva vulva condition not... Central third of the body death or serious disability in a significant percentage of.... 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Is seen in middle aged adults vulva condition is not related to systemic diseases or sunlight the. Freckles on lips is usually thin and light than other areas of the oral mu-cosae ar known, oral. Be found on the term labial melanotic macule. any race, and of either.! Of Dermatology, Western Infirmary, Glasgow, UK dermal counterpart is benign has! Years, 3 months ) women on the tongue that had first noted. Although they usually appear in the lower lip causes Racial pigmentation 20 years since the initial description of melanotic! Have to acknowledge that this is a well-defined, oval, brown to black le-sions, which usually than., Mackie RM as focal melanosis noted at birth currently, there is no specific cause for vulvar! Macule of the lips and termed as the most common melanotic lesions as to its exact.! Has been some uncertainty as to its exact nature causes Racial pigmentation young white women the.

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Dnes jsou cílem k trestání Maďarsko a Polsko, zítra může dojít na nás

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„Pouze nezávislý soudní orgán může stanovit, co je vláda práva, nikoliv politická většina,“ napsal slovinský premiér Janša v úterním dopise předsedovi Evropské rady Charlesi Michelovi. Podpořil tak Polsko a Maďarsko a objevilo se tak třetí veto. Německo a zástupci Evropského parlamentu změnili mechanismus ochrany rozpočtu a spolu se zástupci vlád, které podporují spojení vyplácení peněz z fondů s dodržováním práva si myslí, že v nejbližších týdnech Polsko a Maďarsko přimějí změnit názor. Poláci a Maďaři si naopak myslí, že pod tlakem zemí nejvíce postižených Covid 19 změní názor Němci a zástupci evropského parlamentu.

Mechanismus veta je v Unii běžný. Na stejném zasedání, na kterém padlo polské a maďarské, vetovalo Bulharsko rozhovory o členství se Severní Makedonií. Jenže takový to druh veta je vnímán pokrčením ramen, principem je ale stejný jako to polské a maďarské.

Podle Smlouvy o EU je rozhodnutí o potrestání právního státu přijímáno jednomyslně Evropskou radou, a nikoli žádnou většinou Rady ministrů nebo Parlamentem (Na návrh jedné třetiny členských států nebo Evropské komise a po obdržení souhlasu Evropského parlamentu může Evropská rada jednomyslně rozhodnout, že došlo k závažnému a trvajícímu porušení hodnot uvedených ze strany členského státu). Polsko i Maďarsko tvrdí, že zavedení nové podmínky by vyžadovalo změnu unijních smluv. Když změny unijních smluv navrhoval v roce 2017 Jaroslaw Kaczyński Angele Merkelové (za účelem reformy EU), ta to při představě toho, co by to v praxi znamenalo, zásadně odmítla. Od té doby se s Jaroslawem Kaczyńskim oficiálně nesetkala. Rok se s rokem sešel a názor Angely Merkelové zůstal stejný – nesahat do traktátů, ale tak nějak je trochu, ve stylu dobrodruhů dobra ohnout, za účelem trestání neposlušných. Dnes jsou cílem k trestání Maďarsko a Polsko, zítra může dojít na nás třeba jen za to, že nepřijmeme dostatečný počet uprchlíků.

Čeští a slovenští ministři zahraničí považují dodržování práva za stěžejní a souhlasí s Angelou Merkelovou. Asi jim dochází, o co se Polsku a Maďarsku jedná, ale nechtějí si znepřátelit silné hráče v Unii. Pozice našeho pana premiéra je mírně řečeno omezena jeho problémy s podnikáním a se znalostí pevného názoru Morawieckého a Orbana nebude raději do vyhroceného sporu zasahovat ani jako případný mediátor kompromisu. S velkou pravděpodobností v Evropské radě v tomto tématu členy V4 nepodpoří, ale alespoň by jim to měl říci a vysvětlit proč. Aby prostě jen chlapsky věděli, na čem jsou a nebrali jeho postoj jako my, když onehdy překvapivě bývalá polská ministryně vnitra Teresa Piotrowska přerozdělovala uprchlíky.

Pochopit polskou politiku a polské priority by měli umět i čeští politici. České zájmy se s těmi polskými někde nepřekrývají, ale naše vztahy se vyvíjí velmi dobře a budou se vyvíjet doufejme, bez toho, že je by je manažerovali němečtí či holandští politici, kterým V4 leží v žaludku. Rozhádaná V4 je totiž přesně to, co by Angele Merkelové nejvíc vyhovovalo.

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Morawiecki: Hřbitovy budou na Dušičky uzavřeny

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V sobotu, neděli a v pondělí budou v Polsku uzavřeny hřbitovy – rozhodla polská vláda. Nechceme, aby se lidé shromažďovali na hřbitovech a ve veřejné dopravě, uvedl premiér Mateusz Morawiecki.

„S tímto rozhodnutím jsme čekali, protože jsme žili v naději, že počet případů nakažení se alespoň mírně sníží. Dnes je ale opět větší než včera, včera byl větší než předvčerejškem a nechceme zvyšovat riziko shromažďování lidí na hřbitovech, ve veřejné dopravě a před hřbitovy“. vysvětlil Morawiecki.

Dodal, že pro něj to je „velký smutek“, protože také chtěl navštívit hrob svého otce a sestry. Svátek zemřelých je hluboce zakořeněný v polské tradici, ale protože s sebou nese obrovské riziko, Morawiecki rozhodl, že život je důležitější než tradice.

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Poslankyně opozice atakovaly předsedu PiS

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Ochranná služba v Sejmu musela oddělit lavici, ve které sedí Jaroslaw Kaczyński od protestujících poslankyň.

„Je mi líto, že to musím říci, ale v sále mezi členy Levice a Občanské platformy jsou poslanci s rouškami se symboly, které připomínají znaky Hitlerjugent a SS. Chápu však, že totální opozice odkazuje na totalitní vzorce.“ řekl na začátku zasedání Sejmu místopředseda Sejmu Ryszard Terlecki.

Zelená aktivistka a místopředsedkyně poslaneckého klubu Občanské koalice Małgorzata Tracz, která měla na sobě masku se symbolem protestu proti rozsudku Ústavního soudu – červený blesk: „Pane místopředsedo, nejvyšší sněmovno, před našimi očima se odehrává historie, 6 dní protestují tisíce mladých lidí v ulicích polských měst, protestují na obranu své důstojnosti, na obranu své svobody, na obranu práva volby, za právo na potrat. Toto je válka a tuto válku prohrajete. A kdo je za tuto válku zodpovědný? Pane ministře Kaczyński, to je vaše odpovědnost.“

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  • Dnes jsou cílem k trestání Maďarsko a Polsko, zítra může dojít na nás 19.11.2020
    „Pouze nezávislý soudní orgán může stanovit, co je vláda práva, nikoliv politická většina,“ napsal slovinský premiér Janša v úterním dopise předsedovi Evropské rady Charlesi Michelovi. Podpořil tak Polsko a Maďarsko a objevilo se tak třetí veto. Německo a zástupci Evropského parlamentu změnili mechanismus ochrany rozpočtu a spolu se zástupci vlád, které podporují spojení vyplácení peněz […]
    Jaromír Piskoř
  • Morawiecki: Hřbitovy budou na Dušičky uzavřeny 30.10.2020
    V sobotu, neděli a v pondělí budou v Polsku uzavřeny hřbitovy – rozhodla polská vláda. Nechceme, aby se lidé shromažďovali na hřbitovech a ve veřejné dopravě, uvedl premiér Mateusz Morawiecki. „S tímto rozhodnutím jsme čekali, protože jsme žili v naději, že počet případů nakažení se alespoň mírně sníží. Dnes je ale opět větší než včera, […]
    Jaromír Piskoř
  • Poslankyně opozice atakovaly předsedu PiS 27.10.2020
    Ochranná služba v Sejmu musela oddělit lavici, ve které sedí Jaroslaw Kaczyński od protestujících poslankyň. „Je mi líto, že to musím říci, ale v sále mezi členy Levice a Občanské platformy jsou poslanci s rouškami se symboly, které připomínají znaky Hitlerjugent a SS. Chápu však, že totální opozice odkazuje na totalitní vzorce.“ řekl na začátku […]
    Jaromír Piskoř

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