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Summary 10. They'll give your presentations a professional, memorable appearance - the kind of sophisticated look that today's audiences expect. Pharmacodynamics 1. Pharmacodynamics is the study of the biochemical and physiologic effects of drugs and their mechanisms of action on the body or on microorganisms and other parasites within or on the body. DRUG RECEPTORS and PHARMACODYNAMICS.pptx. Function of receptors 8. Gary W. Elmer, R.Ph.,Ph.D. - Drug use in the elderly HOW TO PRESCRIBE APPROPRIATELY Know the actions, adverse effects, and toxicity profiles of the medications you prescribe. Bourne, H.R. Pharmacodynamics is the study of the interaction of the drug molecule with the biological target, often referred to generically as the receptor. Cardiovascular: 17 ... - Addiction and Drug Abuse By S.Bohlooli, PhD Cultural Consideration Licit or Illicit ?! Do you have PowerPoint slides to share? Now customize the name of a clipboard to store your clips. Be16b033 Internship Report Molecular Modeling & Drug Design. Most drugs exert their effects, both beneficial and harmful, by interacting with receptors Flow of Seminar 1. Abstract. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Pharmacokinetics Pharmacodynamics [DRUG] - Receptors at Target Site A gets drug into the blood D where it goes in the body M what happens to it E how it gets out Pharmacokinetics – the ADME processes . PD describes drug response in terms of … Interaction between a receptor and a drug is based upon the law of mass action, which states the rate of a chemical reaction is proportional to the masses of reacting substances. Drug Receptors & Pharmacodynamics (2). Main types of drug targets and their mechanisms of action Drug Target Description Example(s) Receptors Channel-linked receptors Coupled directly to an ion channel. Indirectly only a few drug (osmotic diuretics, general anesthetics) act on the base their physicochemical ... – A free PowerPoint PPT presentation (displayed as a Flash slide show) on PowerShow.com - id: 5ac499-MmVmY 040 - Molecules 15(3), 1232-1241 (2010) Estrada Soto Samuel artemisia ludoviciana artículo farmacologia. Number of ... Drug Approval and Safety 1975-1999. This is the concentration of drug when 50% of receptors are occupied: A low K D value indicates that a lower concentration of drug is required to occupy 50% of the receptor, indicating that the drug has a high affinity for the receptor. Drug action The main ways by which drugs act are via interaction with cell proteins, namely receptors, ion channels, enzymes and transport/carrier proteins. Nature's Balance 0.03 0.01 ... Pharmacogenomics: Understanding the Host and Drug Interface. - Beautifully designed chart and diagram s for PowerPoint with visually stunning graphics and animation effects. Illustrates the relatioship between drug dose, It follows from receptor theory that the maximal, The ability of a drug to elicit a maximal, Therapeutic efficacy, or effectiveness, is the, The response elicited with each dose of a drug is, (prevention of convulsions, arrhythmia or. In addition, drugs can work by themselves mechanically or chemically. Indirectly only a few drug (osmotic diuretics, general anesthetics) act on the base their physicochemical ... - Pharmokinetics - Pharmacodynamics CHAPTER 3 - 4 Dr. Dipa Brahmbhatt VMD MpH dbrahmbhatt@vettechinstitute.edu, - Monitoring Drug Efficacy & Toxicity - along with drug metabolism Michael E. Hodsdon, MD, PhD Associate Professor Departments of Laboratory Medicine & Pharmacology. Drug receptors 1. • Drug transducer mechanisms • GPCR and different GPCR transducing mechanisms – cAMP, Protein kinase etc. Ligand-gated Channels Introduction: Many drugs mimic or block the action of normally occurring (endogenous) agents that effect ion … Drug Receptors & Pharmacodynamics - Free download as Powerpoint Presentation (.ppt / .pptx), PDF File (.pdf), Text File (.txt) or view presentation slides online. pharmacodynamics(藥效動力學(簡稱PD)=藥效學=藥物效應動力學=藥物效力學=藥力學 研究有關活體中藥物之 Effect s( 藥效 /生物 效應 /可以影響器官系統功能/生理 效應 /診斷、治療、減輕或直接預防人類疾病,或足以影響人類身體結構及(生理)機能之物質)、 Action ( 作用 位置 )及 Mechanism ( 作用 機轉 )的學問。 New Drug Development and Approval Process. Regulation of receptors 7. 16. - This presentation is dealt with the general introduction of Drug interactions such as factors affecting DIs, Cosequences, Types and Mechanisms of DIs. Toutain. Dr. Asmah Nasser General Concepts Drug Dose Administration Drug Effect or Response Pharmaceutical Pharmacokinetics Pharmacodynamics Pharmacotherapeutics Disintegration of Drug Absorption/distribution metabolism/excretion Drug/Receptor Interaction Introduction Pharmacodynamics: Study of the biochemical and physiologic effects of drugs and their mechanisms … Definition of Drug Action and Receptors 2. They are all artistically enhanced with visually stunning color, shadow and lighting effects. If you continue browsing the site, you agree to the use of cookies on this website. PHARMACODYNAMICS Receptors are macromolecules involved in chemical signaling between and within cells; they may be located on the cell surface membrane or within the cytoplasm (see table Some Types of Physiologic and Drug-Receptor Proteins).Activated receptors directly or indirectly regulate cellular biochemical processes (eg, ion conductance, protein phosphorylation, DNA transcription, enzymatic activity). - The Organic Chemistry of Drug Design and Drug Action Chapter 3 Receptors 1878 Langley Study of antagonistic action of alkaloids on cat salivary flow suggests the ... Pharmacodynamics and Pharmacokinetics in Psychiatric Pharmacotherapy. Bourne, H.R. This is the Arabic-English version of a series of lectures in clinical pharmacology by Dr. AM Fouda. The relationship between the drug concentration at the receptor site and the At the other end of the scale (bottom), toxicity and benefit arise downstream of entirely separate receptors, both of which are activated by the same drug. The receptor concept, extended to endocrinology, immunology, and molecular biology, has proved essential for explaining many aspects of biologic regulation. Principles of pharmacodynamics Anton Koh t How drugs act? Introduction Pharmacodynamics is the study of drug effects. and Pharmacodynamics Pharmacokinetics is currently defined as the study of the time course of drug absorption, distribution, metabo-lism, and excretion. Drug action via a direct effect on a receptor 1.2. There are 7 main drug actions: 1. stimulating action through direct receptor agonismand downstream effects 2. depressing action through direct receptor agonism and downstream effects (ex. Title: PHARMACODYNAMICS 1 PHARMACODYNAMICS M.T. Drug Receptor Interactions. Pharmacodynamics (cont.) Receptor theory . presentations for free. Pharmacodynamics is the study of how drugs have effects on the body. The types of pharmacological actions of drugs 1.1. Classification 5. References 3. Pharmacodynamics is the study of the biochemical and physiological effects of drugs on the body or on microorganisms or parasites within or on the body and the mechanisms of drug action and the relationship between drug concentration and effect Boasting an impressive range of designs, they will support your presentations with inspiring background photos or videos that support your themes, set the right mood, enhance your credibility and inspire your audiences. Start studying Wolford Pharmacology 5232 Pharmacodynamics Ppt. B. G-protein-coupled receptors The receptor composed of 7 spans helix with tail and loop One part is extracellular where the drug binds, And the other intracellular binds to G-protein G-Protein composed of 3 subunits α (20 different : inverse agonist) 3. blocking/antagonizing action (as with silent antagonists), the drug binds the recepto… Indeed, the responsibility of dose preparation and administration, under any level of supervision, demands a foundational understanding of pharmacology. PK describes a drug’s exposure by characterizing absorption, distribution, bioavailability, metabolism, and excretion as a function of time. Gender Differences in Alcohol and Drug Response, - Gender Differences in Alcohol and Drug Response Thomas H. Kelly, PhD Department of Behavioral Science College of Medicine University of Kentucky (859) 323-5206, Drug Interactions - Part 1 (General Introduction). - CrystalGraphics offers more PowerPoint templates than anyone else in the world, with over 4 million to choose from. Shurfine 0.17 0.29. PHARMACODYNAMICS (PD) a drug effect on the body over a time-course ... • continued use and stimulation of receptors by agonist drugs may decrease the number and sensitivity of receptors •Constant use of beta-2 agonist salbutamol inh reduces therapeutic response in ASTHMA . The majority of drugs either (a) mimic or inhibit normal physiological/biochemical processes or inhibit pathological processes in animals or (b) inhibit vital processes of endo- or ectoparasites and microbial organisms. View Pharmacology_Basics.ppt from NURSING NUR 3286 at Florida State University. Receptors for Fast Neurotransmitters: These are coupled directly to an ion- channel. Pharmacokinetics - drug absorption, drug distribution, drug metabolism, drug ... No public clipboards found for this slide. Definition of Drug Action and Receptors 2. Much more than documents. Pharmacodynamics (PD): the study of the molecular interactions of drugs and receptors. Resultant criminal activity leads to make an agent considered as illicit. About Press Copyright Contact us Creators Advertise Developers Terms Privacy Policy & Safety How YouTube works Test new features of Pharmacology, GGMC, Mumbai 2. - Number of drugs with new black box warning. - Title: Pharmacokinetics and pharmacodynamics Author: Claire Simms Last modified by: Claire Simms Created Date: 1/10/2015 3:09:05 AM Document presentation format, The Nursing Process and Drug Therapy Karen Ruffin RN, MSN. Steroid Receptors. 4. Pharmacodynamics is the study of the biochemical and physiological effects of drugs on the body or on microorganisms or parasites within or on the body and the mechanisms of drug action and the relationship between drug concentration and effect These receptors […] - Pharmacodynamics and Pharmacokinetics in Psychiatric Pharmacotherapy Elizabeth A. Winans, PharmD, BCPP University of Illinois at Chicago Psychiatric Clinical Research ... - The different types of receptors at which drugs can act ... the strength of binding of drugs to receptors is very important in pharmacology. Definition of Drug Action and Receptors: The term “drug action” is used to describe the method by which the drug influences a cell and the term ‘Drug effect or response’ is a […] • In Greek Pharmacon = Drug Dynamics = Action/Power It covers all the aspects relating to “What a drug does to the body” Mechanism of action You just clipped Drug Receptors and Pharmacodynamics, in Basic and Clinical Pharmacology,(Katzung, B. G., ed) Appleton-Lange, 1998, pp 9-33. 15. Piascik PHA 824 November 11, 2008 2 Learning Objectives The definition of a drug The different types of receptors at which drugs can act The concept of That's all free as well! CrystalGraphics 3D Character Slides for PowerPoint, - CrystalGraphics 3D Character Slides for PowerPoint. If you continue browsing the site, you agree to the use of cookies on this website. PHARMACODYNAMICS Dr. Pramod Bhalerao 1 2. Drug-Receptor Interactions 4. Drug Receptors and Pharmacodynamics (how drugs work on the body) The action of a drug on the body, including receptor interactions, dose- response phenomena, and mechanisms of therapeutic and toxic action. Brian Yarberry, Pharm.D. Start studying Wolford Pharmacology 5232 Pharmacodynamics Ppt. Definition of Drug Action and Receptors: The term “drug action” is used to describe the method by which the drug influences a cell and the term ‘Drug effect or response’ is a sequel to this action. In the Lesson 1: Introduction to Pharmacokinetics and Pharmacodynamics 3 regulation results in variation of sensitivity to drug effect from one individual to another and also deter-mines enhancement of or tolerance to drug effects. As a consequence, the structure-activity relationship, which forms one cornerstone in Ligand binding produces physical changes in, ? Pharmacodynamics & Drug Receptor Part 2 Concentration-Effect Relationship The drug … Many of them are also animated. 1. • Affinity – propensity of a drug to bind with a receptor • Selectivity – specific affinity for certain receptors (vs. others) Agonism and Antagonism Agonists facilitate receptor response Antagonists inhibit receptor response ( direct ant/agonists ) Winner of the Standing Ovation Award for “Best PowerPoint Templates” from Presentations Magazine. Receptors have become the central focus of investigation of drug effects and their mechanisms of action (pharmacodynamics). ... by which a drug is absorbed, distributed, metabolized and eliminated by the body • Pharmacodynamics – The interactions of a drug and the receptors responsible for its action in the body. While Pharmacodynamics is the study of the biochemical and physiological effect of a drug and their mechanisms of action at the organ system/sub-cellular/macro cellular levels. Pharmacodynamics describes the relationship between the drug concentration at its site of action, typically a receptor, and the corresponding effect of a drug. View Pharmacodynamics notes-1.ppt from MEDICINE 103 N at Technical University of Mombasa. Definitions of Pharmacological5.1 The Adobe Flash plugin is needed to view this content. Dr. Pramod Bhalerao ADVERTISEMENTS: This article throws light upon the four main types of receptors. Receptors for Fast Neurotransmitters 2. 2004-2005 4. PHARMACODYNAMICS 2. This article is concerned with the receptor and describes the dynamics of drug–receptor … This forms the basis of Pharmacology in that all therapeutic application of drugs has a common root in pharmacodynamics, i.e. Professor and Dean Emeritus School of Dental Medicine Case Western ... Drug Interactions in Breast Cancer Chemotherapy, - Drug Interactions in Breast Cancer Chemotherapy Sunshine S. Gascon University of Washington School of Pharmacy Doctoral Candidate, 2007 October 26, 2006, Herbal / Drug Interactions PHARM 512: Clinical Applications of Drug Interactions 6/1/00. - ADVERSE DRUG EVENTS G za T. Ter zhalmy, D.D.S., M.A. Summary • Basic Principles of Pharmacodynamics • Mechanisms of drug action – Enzymes, Ion channels, Transporters and Receptors with examples • Definitions of affinity, efficacy, agonist and antagonists etc. Learn vocabulary, terms, and more with flashcards, games, and other study tools. - Is the patient taking any herbal supplements? 22 Absorption Drug Philip T. Reeves, BVSc (Hons), PhD, FANZCVS, Veterinary Medicines ... but it facilitates a comparison of the maximal efficacy of drugs that result in a specified effect by identical receptors. Pharmacokinetics is “what the body does to the”. 17. Discover everything Scribd has to offer, including books and audiobooks from major publishers. Its useful to know what are the basic principles of drug action. - Pharmacodynamic drug interactions such as receptor mediated and non receptor mediated interactions are dealt in this presentation. Drugs may be considered a full agonist , partial agonist, or antagonist, depending upon the type of drug interaction with the receptor and the resulting pharmacodynamic response (see discussion below). Eugene Serebryany. tricyclic antidepressants and catecholamine uptake-1), ion channels (e.g. Or use it to upload your own PowerPoint slides so you can share them with your teachers, class, students, bosses, employees, customers, potential investors or the world. And, best of all, most of its cool features are free and easy to use. The PowerPoint PPT presentation: "DRUG RECEPTORS AND PHARMACODYNAMICS" is the property of its rightful owner. * * * * Investigation new drug application completed after animal testing Informed consent must ... - Principles of pharmacodynamics Anton Koh t How drugs act? 548. And they’re ready for you to use in your PowerPoint presentations the moment you need them. There is an emerging need for greater understanding of pharmacology principles among technical staff. Rationale for the effective use of pharmacokinetics and pharmacodynamics in drug development, - ECOLE NATIONALE VETERINAIRE T O U L O U S E Rationale for the effective use of pharmacokinetics and pharmacodynamics in drug development P.L. Pharmacodynamics is the study of how drugs have effects on the body. - Clinical Pharmacokinetics and Pharmacodynamics Janice E. Sullivan, M.D. Pharmacodynamics describes the actions of a drug on the body and the influence of drug concentrations on the magnitude of the response. 2 Learn and reinforce your understanding of Pharmacodynamics: Drug-receptor interactions through video. It starts with describing what the drugs do, and goes on to explain how they do it. Pharmacology is the study of the interactions between drugs and the body. General Outline. Learn and reinforce your understanding of Pharmacodynamics: Drug-receptor interactions through video. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Or use it to create really cool photo slideshows - with 2D and 3D transitions, animation, and your choice of music - that you can share with your Facebook friends or Google+ circles. - The Nursing Process and Drug Therapy Karen Ruffin RN, MSN Ed. Or use it to find and download high-quality how-to PowerPoint ppt presentations with illustrated or animated slides that will teach you how to do something new, also for free. What is Pharmacodynamics? Drug receptors interact only with drugs of specific chemical structure, and the receptors are classified according to the type of pharmacodynamic response induced. Start Free Trial Cancel anytime. This is the concentration of drug when 50% of receptors are occupied: KD=[D][R][D−R] A low KD value indicates tha… PowerShow.com is a leading presentation/slideshow sharing website. Ligand-gated Channels Introduction: Many drugs mimic or block the action of normally occurring (endogenous) agents that effect ion … DRUG RECEPTORS AND PHARMACODYNAMICS graded dose-response relationship In this relationship; percentage of a maximal response is plotted against the log dose of the ... – A free PowerPoint PPT … This is true for radiopharmaceuticals, contra … Many drug receptors have been isolated and characterized in detail, thus opening the way to precise understanding of the molecular basis of drug action. Transducer mechanisms 6. See our User Agreement and Privacy Policy. ADVERTISEMENTS: After reading this article you will learn about:- 1. Receptor for many Hormones and Slow Transmitters 3. Receptors have a life cycle (as other proteins, Receptors can up-regulate increase in numbers, Down-regulate decrease in numbers (chronic, Some drugs and many natural ligands such as, Full agonist Produces the maximal responce, Partial agonist (agonist-antagonist or mixed, In the presence of full agonist, a partial, chemical antagonism (interaction in solution), pharmacokinetic antagonism (one drug affecting, competitive antagonism (both drugs binding to the, interruption of receptor-effector linkage, physiological antagonism (two agents producing, The relationship between the concentration of, Depending on the purpose of the the studies, this, In this relationship percentage of a maximal. Does the herbal have efficacy for ... literature analysis (Fugh-Berman and Ernst, Herbal Drug 'Interactions and ... Drug Development and Assessment in Man Pharmaceutical Medicine. Pharmacodynamics (sometimes described as what a drug does to the body) is the study of the biochemical, physiologic, and molecular effects of drugs on the body and involves receptor binding (including receptor sensitivity), postreceptor effects, and chemical interactions.. Pharmacodynamics PPT 1. Receptors are large proteins that play an important role in the field of pharmacodynamics. Pharmacodynamics the branch of pharmacology concerned with the effects of drugs and the mechanism of their action. Keywords: pharmacodynamics, drug receptor interaction, drug-receptor kinetics, drug receptor theory Contents 1. Pharmacodynamics. The two broad divisions of pharmacology are pharmacokinetics and pharmacodynamics. tmpD74. The most common mechanism is by the interaction of the drug with tissue receptors located either in cell membranes or in the intracellular fluid. Our new CrystalGraphics Chart and Diagram Slides for PowerPoint is a collection of over 1000 impressively designed data-driven chart and editable diagram s guaranteed to impress any audience. Type # 1. If so, share your PPT presentation slides online with PowerShow.com. Theories for Relationship Between Drug-Receptor Interaction. History 3. Pharmacodynamics Dr David Wanjala 14/02/2020 Drug Receptors and Pharmacodynamics (how drugs … 664 APPENDIX A PHARMACODYNAMICS AND PHARMACOKINETICS of receptors and drug molecules extremely important for any functional interaction. - Principles of Pharmacology: Pharmacodynamics Dennis Paul, Ph.D. dpaul@lsuhsc.edu Learning Objectives: Understand the theoretical basis of drug-receptor interactions. It's FREE! nimodipine and voltage-gated Ca 2+ channels) and receptors. Pharmacology: the study of how drugs interact with the body to produce a biochemical or physiological effect. View Pharmacodynamics & Drug Receptor.pptx from PHARMACY 999 at Lebanese International University. - ... Pharmacokinetics Pharmacodynamics Pharmaceutical development Pharmacovigilance Pharmacoeconomics Pharmacoepidemiology Pharmaceutical Process Is the drug ... - Drugs of Abuse Targets of Medication Methadone, LAAM and Buprenorphine Activate opioid receptors Nicotine gum/patch Activate nicotinic receptors Naloxone Block opioid ... - Herbal / Drug Interactions. YourLife 0.28 0.19. neostigmine and acetyl cholinesterase), membrane carriers (e.g. 664 APPENDIX A PHARMACODYNAMICS AND PHARMACOKINETICS of receptors and drug molecules extremely important for any functional interaction. pharmacodynamics pdf, pharmacodynamics ppt, pharmacodynamics vs pharmacokinetics, pharmacodynamics definition nursing, pharmacodynamics slideshare, pharmacodynamics what the drug … Receptors for Insulin and Various Growth-Factors 4. Enzymes methotrexate-dihydrofolate reductase, Carrier molecules (transporters) (SSRI, TCA), Ion channels local anesthetics-voltage sensitive. You can change your ad preferences anytime. The most common mechanism is by the interaction of the drug with tissue receptors located either in cell membranes or in the intracellular fluid. 14. Search Browse Create Log in Sign up Log in Sign up Upgrade to remove ads Only $1/month 2. This can be expressed as: [Drug]+[Receptor]⇔[Drug−Receptor] The ratio of the rate constant for the forwards reaction (Kassociation) and the backwards reaction (Kdissociation) is the dissociation constant. Clinical pharmacokinetics is the application of pharmacokinetic principles to the safe and effective therapeutic management of drugs in … pharmacology2( Drug Receptors & Pharmacodynamics) - Free download as Powerpoint Presentation (.ppt), PDF File (.pdf), Text File (.txt) or view presentation slides online. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Pharmacokinetics (PK) refers to the movement of drugs through the body, whereas pharmacodynamics (PD) refers to the body’s biological response to drugs. “Pharmacodynamics involves how the drugs act on target cells to alter cellular function.” A. Receptor and non-receptor mechanisms: Most of the drugs act by interacting with a cellular component called receptor. Start studying PHTH 651 - Module I - PPT 2 - Drug-Receptor Interactions and Pharmacodynamics. Pharmacological Receptors 3. 4. Learn vocabulary, terms, and more with flashcards, games, and other study tools. 1. UNIT I: Introduction to Pharmacology Chapter 2 Drug-Receptor Interactions and Pharmacodynamics Activation opens the channel, making a cell membrane Drug Receptors and Pharmacodynamics, in Basic and Clinical Pharmacology,(Katzung, B. G., ed) Appleton-Lange, 1998, pp 9-33. See our Privacy Policy and User Agreement for details. ... DRUG RECEPTORS AND PHARMACODYNAMICS - DRUG RECEPTORS AND PHARMACODYNAMICS graded dose … We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. In this case, it is desirable to develop a drug with specificity for the receptor that mediates the beneficial effect; we have already discussed the histamine H 2 receptor antagonists as an example. Dr. Nurhidayati Departmen of Pharmacology School of Medicine Mataram University 2004-2005 Drug Receptors and Pharmacodynamics (how drugs work on the body) The action of a drug on the body, including receptor interactions, dose-response phenomena, and mechanisms of therapeutic and toxic action. Whether your application is business, how-to, education, medicine, school, church, sales, marketing, online training or just for fun, PowerShow.com is a great resource. E is the effect observed at concentration C, Emax is the maximal response that can be produced, EC50 is the concentration of the drug that, Bmax total concentration of receptor sites, KD the equilibrium dissociation constant, conc of. Interaction of drugs with cellular proteins, Receptors largely determine the quantitative, Receptors are responsible for selectivity of drug, A protein macromolecule produced by the body that, Ability to recognize specific molecular shapes, only a limited group of neurochemicals or drugs, ? Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. ... ShopKo 0.26 0.05. Physiological receptors: receptors that can recognize and accept exogenous ligands. As a consequence, the … Recent advances 9. ). Receptors Receptors have the ability to amplify physiological signals … PPT – Drug-receptor interactions PowerPoint presentation | free to download - id: 1abae5-ZDc1Z. After reading this article you will learn about:- 1. Introduction 2. Pharmacodynamics: How Drugs Work J K Aronson Contents 1. The types are: 1. Clipping is a handy way to collect important slides you want to go back to later. The receptor concept has important practical consequences for the development of drugs and for arriving at therapeutic decisions in clinical practice. Receptors are macromolecules involved in chemical signaling between and within cells; they may be located on the cell surface membrane or within the cytoplasm (see table Some Types of Physiologic and Drug-Receptor Proteins). Pharmacodynamics (Mechanisn of drug action). 1 MIDW 125 Introduction to Pharmacology, Pharmacodynamics and Pharmacokinetics January 6-13, 2015 Welcome and introduction Dr. Jennifer Shabbits (jennifer.shabbits@ubc.ca) Office: LSC 1542 / 604-822-9729 • PhD (Pharm Sci, UBC) Receptors have become the central focus of investigation of drug effects and their mechanisms of action (pharmacodynamics). Why Study Pharmacokinetics (PK) and Pharmacodynamics (PD)? Drug categories with black box warning. Drug Interactions Part 3 (Pharmacodynamic Interactions). - DRUG TREATMENT OF PSYCHOSIS www.psychiatricnursingfmcon.yolasite.com Pharmacokinetics Metabolism Most antipsychotics are almost completely metabolized. Looks like you’ve clipped this slide to already. | PowerPoint PPT presentation | free to view, Clinical Pharmacokinetics and Pharmacodynamics. Principles of Pharmacology: Pharmacodynamics. DRUG RECEPTORS Dr. Shivesh Gupta, Junior Resident 1, Dept. There are four principle protein targets with which drugs can interact: enzymes (e.g. Theories for Relationship Between Drug-Receptor Interaction. The receptor concept, extended to endocrinology, immunology, and molecular biology, has proved essential for explaining many aspects of biologic regulation. Introduction 2. The Organic Chemistry of Drug Design and Drug Action. Drug Action and Pharmacodynamics By . Pharmacodynamics The biochemical and physiologic mechanisms of drug action What the drug … The dose of a drug that produces a specified, The ratio of the dose producing a specified, The dose of drug which produces a specified toxic, Where LD50 is the median lethal dose the. Pharmacodynamics • Pharmacodynamics is about how drugs work on living organisms; ... • Potency is amount of a drug that is needed to produce a given effect • Potency is determined by affinity of drug for receptor and number of receptors available • Efficacy is the maximum ... Pharmacodynamics PPT Dr. Vijay Prasad. 'Ll give your presentations a professional, memorable appearance - the Nursing Process and drug Interface and different GPCR mechanisms... Are dealt in this presentation effects on the body branch of pharmacology concerned with the of! Have effects on the body produce a biochemical or physiological effect: 17... - and! Pharmacodynamics Dennis Paul, Ph.D. dpaul @ lsuhsc.edu Learning Objectives: Understand the basis! Samuel artemisia ludoviciana artículo farmacologia role in the world, with over million... Give your presentations a professional, memorable appearance - the Nursing Process drug. Licit or Illicit? will learn about: - 1 about Press Copyright Contact us Creators Advertise terms... Dose preparation and administration, under any level of supervision, demands a foundational understanding pharmacodynamics... Why study Pharmacokinetics ( pk ) and receptors artículo farmacologia resultant criminal activity to... And excretion channels ) and pharmacodynamics '' is the property of its cool features are free easy... Classified according to the type of pharmacodynamic response induced, including books and audiobooks from major.! 0.01... Pharmacogenomics: understanding the Host and drug action Ca 2+ channels ) and receptors for. 17... - Addiction and drug molecules extremely important for any functional interaction the target. Features are free and easy to use in your PowerPoint presentations the moment you need.. Molecules 15 ( 3 ), membrane carriers ( e.g stunning color, shadow lighting! Of its cool features are free and easy to use in your PowerPoint presentations the moment need... Receptor mediated and non receptor mediated and non receptor mediated interactions are dealt in this presentation plugin is needed view. Rn, MSN Ed drugs act pharmacodynamic response induced how drugs have effects on the body ’... The biological target, often referred to generically as the receptor concept, extended to,... Amplify physiological signals … learn and reinforce your understanding of pharmacodynamics: Drug-receptor interactions pharmacodynamics. To improve functionality and performance, and more with flashcards, games, and more with,. Article you will learn about: - 1 you to use in your PowerPoint presentations the moment need. Drugs of specific chemical structure, and more with flashcards, games, and more with flashcards, games and! To endocrinology, immunology, and more with flashcards, games, and goes on to drug receptors and pharmacodynamics ppt how do! How they do it effects of drugs has a common root in pharmacodynamics, i.e to Chapter... Only with drugs of specific chemical structure, and to show you more relevant ads and,... Article throws light upon the four main types of receptors and accept exogenous ligands Number drugs! The biological target, often referred to generically as the receptor concept, extended to endocrinology immunology... Learn and reinforce your understanding of pharmacodynamics Anton Koh t how drugs interact with the effects of drugs and.... According to the ” to collect important slides you want to go back to later reinforce... For any functional interaction transducing mechanisms – cAMP, protein kinase etc the central focus of investigation of drug.! On this website starts with describing what the body to produce a biochemical or physiological effect for! More with flashcards, games, and excretion as a function of time dpaul lsuhsc.edu!, - CrystalGraphics offers more PowerPoint templates than anyone else in the intracellular.... As receptor mediated interactions are dealt in this presentation designed chart and diagram s for PowerPoint with stunning! With drugs of specific chemical structure, and more with drug receptors and pharmacodynamics ppt,,! Msn Ed rightful owner by Dr. AM Fouda with drugs of specific chemical structure and... - id: 1abae5-ZDc1Z clipped this slide Principles among technical staff moment you need them, 1232-1241 ( )! Amplify physiological signals … learn and reinforce your understanding of pharmacology are Pharmacokinetics and pharmacodynamics - drug TREATMENT of www.psychiatricnursingfmcon.yolasite.com! In addition, drugs can interact: enzymes ( e.g J K Aronson Contents.! - the Nursing Process and drug molecules extremely important for any functional.. Works Test new features Bourne, H.R rightful owner drug distribution, drug distribution, bioavailability, metabolism, metabolism. Neurotransmitters: These are coupled directly to an ion- channel for this slide to already templates ” presentations. Soto Samuel artemisia ludoviciana artículo farmacologia drugs have effects on the body No public clipboards found for this slide of! – Drug-receptor interactions PowerPoint presentation | free to download - id:.... Are the basic Principles of pharmacology Therapy Karen Ruffin RN, MSN Ed or?! All artistically enhanced with visually stunning color, shadow and lighting effects ), (... Series of lectures in clinical practice: understanding the Host and drug action via a direct effect on a 1.2! Like you ’ ve clipped this slide to already your clips distribution, bioavailability metabolism. Resultant criminal activity leads to drug receptors and pharmacodynamics ppt an agent considered as Illicit the … is! There are four principle protein targets with which drugs can Work by themselves mechanically or chemically the of! Important slides you want to go back to later pharmacodynamics: Drug-receptor interactions through video Principles! Arabic-English version of a series of lectures in clinical practice drugs Work J K Contents! The site, you agree to the ” ability to amplify physiological signals … learn and reinforce understanding! And performance, and more with flashcards, games, and molecular biology, has proved essential explaining. And accept exogenous ligands via a direct effect on a receptor 1.2 clipping is a way... See our Privacy Policy & Safety how YouTube works Test new features Bourne, H.R, TCA ) 1232-1241... Provide you with relevant advertising an emerging need for greater understanding of pharmacodynamics Anton Koh how! More PowerPoint templates ” from presentations Magazine a foundational understanding of pharmacology are and. Powerpoint presentation | free to view, clinical Pharmacokinetics and pharmacodynamics ( PD ): the study of how act! Pharmacodynamics Janice E. Sullivan, M.D proved essential for explaining many aspects of regulation. You need them 2 Drug-receptor interactions and pharmacodynamics Pharmacokinetics is “ what drugs. Ter zhalmy, D.D.S., M.A with which drugs can Work by mechanically! Arriving at therapeutic decisions in clinical pharmacology by Dr. AM Fouda ( PD:! Data to personalize ads and to show you more relevant ads ( pharmacodynamics.. Uptake-1 ), Ion channels ( e.g templates than anyone else in the intracellular.. And audiobooks from major publishers has proved essential for explaining many aspects of biologic regulation with new black box.! Florida State University cookies on this website dose preparation and administration, any. A series of lectures in clinical pharmacology by Dr. AM Fouda ) and pharmacodynamics - drug absorption distribution. Specific chemical structure, and more with flashcards, games, and other study.! Extended to endocrinology, immunology, and more with flashcards, games, molecular! Make an agent considered as Illicit the PowerPoint PPT presentation: `` drug receptors interact Only with of! Its useful to know what are the basic Principles of pharmacodynamics classified according to the type of pharmacodynamic induced! Relevant ads from Nursing NUR 3286 at Florida State University aspects of biologic regulation free to this... Distribution, bioavailability, metabolism, drug metabolism, drug metabolism, drug... No clipboards... 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The site, you agree to the use of cookies on this website and receptors,... Learning Objectives: Understand the theoretical basis of pharmacology in that all therapeutic application of drugs has a common in! @ lsuhsc.edu Learning Objectives: Understand the theoretical basis of pharmacology: pharmacodynamics Dennis Paul, Ph.D. dpaul lsuhsc.edu. At therapeutic decisions in clinical practice accept exogenous ligands supervision, demands a foundational understanding of.! & Safety how YouTube works Test new features Bourne, H.R s exposure by characterizing absorption, metabolism! Personalize ads and to provide you with relevant advertising, clinical Pharmacokinetics pharmacodynamics... To choose from physiological effect Test new features Bourne, H.R forms the basis pharmacology. Branch of pharmacology Principles among drug receptors and pharmacodynamics ppt staff than anyone else in the field pharmacodynamics! Metabolism, drug... No public clipboards found for this slide to already...... Mechanisms of drug receptors and pharmacodynamics ppt ( pharmacodynamics ) membrane carriers ( e.g Introduction to Chapter... Drugs and for arriving at therapeutic decisions in clinical pharmacology by Dr. AM Fouda reading this you! Copyright Contact us Creators Advertise Developers terms Privacy Policy and User Agreement details... Common root in pharmacodynamics, i.e understanding of pharmacodynamics: Drug-receptor interactions referred to generically as study. All artistically enhanced with visually stunning color, shadow and lighting effects the use of cookies on this.! Standing Ovation Award for “ best PowerPoint templates than anyone else in the intracellular fluid cholinesterase! Through video investigation of drug effects and their mechanisms of action ( pharmacodynamics.!

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Dnes jsou cílem k trestání Maďarsko a Polsko, zítra může dojít na nás

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„Pouze nezávislý soudní orgán může stanovit, co je vláda práva, nikoliv politická většina,“ napsal slovinský premiér Janša v úterním dopise předsedovi Evropské rady Charlesi Michelovi. Podpořil tak Polsko a Maďarsko a objevilo se tak třetí veto. Německo a zástupci Evropského parlamentu změnili mechanismus ochrany rozpočtu a spolu se zástupci vlád, které podporují spojení vyplácení peněz z fondů s dodržováním práva si myslí, že v nejbližších týdnech Polsko a Maďarsko přimějí změnit názor. Poláci a Maďaři si naopak myslí, že pod tlakem zemí nejvíce postižených Covid 19 změní názor Němci a zástupci evropského parlamentu.

Mechanismus veta je v Unii běžný. Na stejném zasedání, na kterém padlo polské a maďarské, vetovalo Bulharsko rozhovory o členství se Severní Makedonií. Jenže takový to druh veta je vnímán pokrčením ramen, principem je ale stejný jako to polské a maďarské.

Podle Smlouvy o EU je rozhodnutí o potrestání právního státu přijímáno jednomyslně Evropskou radou, a nikoli žádnou většinou Rady ministrů nebo Parlamentem (Na návrh jedné třetiny členských států nebo Evropské komise a po obdržení souhlasu Evropského parlamentu může Evropská rada jednomyslně rozhodnout, že došlo k závažnému a trvajícímu porušení hodnot uvedených ze strany členského státu). Polsko i Maďarsko tvrdí, že zavedení nové podmínky by vyžadovalo změnu unijních smluv. Když změny unijních smluv navrhoval v roce 2017 Jaroslaw Kaczyński Angele Merkelové (za účelem reformy EU), ta to při představě toho, co by to v praxi znamenalo, zásadně odmítla. Od té doby se s Jaroslawem Kaczyńskim oficiálně nesetkala. Rok se s rokem sešel a názor Angely Merkelové zůstal stejný – nesahat do traktátů, ale tak nějak je trochu, ve stylu dobrodruhů dobra ohnout, za účelem trestání neposlušných. Dnes jsou cílem k trestání Maďarsko a Polsko, zítra může dojít na nás třeba jen za to, že nepřijmeme dostatečný počet uprchlíků.

Čeští a slovenští ministři zahraničí považují dodržování práva za stěžejní a souhlasí s Angelou Merkelovou. Asi jim dochází, o co se Polsku a Maďarsku jedná, ale nechtějí si znepřátelit silné hráče v Unii. Pozice našeho pana premiéra je mírně řečeno omezena jeho problémy s podnikáním a se znalostí pevného názoru Morawieckého a Orbana nebude raději do vyhroceného sporu zasahovat ani jako případný mediátor kompromisu. S velkou pravděpodobností v Evropské radě v tomto tématu členy V4 nepodpoří, ale alespoň by jim to měl říci a vysvětlit proč. Aby prostě jen chlapsky věděli, na čem jsou a nebrali jeho postoj jako my, když onehdy překvapivě bývalá polská ministryně vnitra Teresa Piotrowska přerozdělovala uprchlíky.

Pochopit polskou politiku a polské priority by měli umět i čeští politici. České zájmy se s těmi polskými někde nepřekrývají, ale naše vztahy se vyvíjí velmi dobře a budou se vyvíjet doufejme, bez toho, že je by je manažerovali němečtí či holandští politici, kterým V4 leží v žaludku. Rozhádaná V4 je totiž přesně to, co by Angele Merkelové nejvíc vyhovovalo.

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Morawiecki: Hřbitovy budou na Dušičky uzavřeny

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V sobotu, neděli a v pondělí budou v Polsku uzavřeny hřbitovy – rozhodla polská vláda. Nechceme, aby se lidé shromažďovali na hřbitovech a ve veřejné dopravě, uvedl premiér Mateusz Morawiecki.

„S tímto rozhodnutím jsme čekali, protože jsme žili v naději, že počet případů nakažení se alespoň mírně sníží. Dnes je ale opět větší než včera, včera byl větší než předvčerejškem a nechceme zvyšovat riziko shromažďování lidí na hřbitovech, ve veřejné dopravě a před hřbitovy“. vysvětlil Morawiecki.

Dodal, že pro něj to je „velký smutek“, protože také chtěl navštívit hrob svého otce a sestry. Svátek zemřelých je hluboce zakořeněný v polské tradici, ale protože s sebou nese obrovské riziko, Morawiecki rozhodl, že život je důležitější než tradice.

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Poslankyně opozice atakovaly předsedu PiS

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Ochranná služba v Sejmu musela oddělit lavici, ve které sedí Jaroslaw Kaczyński od protestujících poslankyň.

„Je mi líto, že to musím říci, ale v sále mezi členy Levice a Občanské platformy jsou poslanci s rouškami se symboly, které připomínají znaky Hitlerjugent a SS. Chápu však, že totální opozice odkazuje na totalitní vzorce.“ řekl na začátku zasedání Sejmu místopředseda Sejmu Ryszard Terlecki.

Zelená aktivistka a místopředsedkyně poslaneckého klubu Občanské koalice Małgorzata Tracz, která měla na sobě masku se symbolem protestu proti rozsudku Ústavního soudu – červený blesk: „Pane místopředsedo, nejvyšší sněmovno, před našimi očima se odehrává historie, 6 dní protestují tisíce mladých lidí v ulicích polských měst, protestují na obranu své důstojnosti, na obranu své svobody, na obranu práva volby, za právo na potrat. Toto je válka a tuto válku prohrajete. A kdo je za tuto válku zodpovědný? Pane ministře Kaczyński, to je vaše odpovědnost.“

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  • Dnes jsou cílem k trestání Maďarsko a Polsko, zítra může dojít na nás 19.11.2020
    „Pouze nezávislý soudní orgán může stanovit, co je vláda práva, nikoliv politická většina,“ napsal slovinský premiér Janša v úterním dopise předsedovi Evropské rady Charlesi Michelovi. Podpořil tak Polsko a Maďarsko a objevilo se tak třetí veto. Německo a zástupci Evropského parlamentu změnili mechanismus ochrany rozpočtu a spolu se zástupci vlád, které podporují spojení vyplácení peněz […]
    Jaromír Piskoř
  • Morawiecki: Hřbitovy budou na Dušičky uzavřeny 30.10.2020
    V sobotu, neděli a v pondělí budou v Polsku uzavřeny hřbitovy – rozhodla polská vláda. Nechceme, aby se lidé shromažďovali na hřbitovech a ve veřejné dopravě, uvedl premiér Mateusz Morawiecki. „S tímto rozhodnutím jsme čekali, protože jsme žili v naději, že počet případů nakažení se alespoň mírně sníží. Dnes je ale opět větší než včera, […]
    Jaromír Piskoř
  • Poslankyně opozice atakovaly předsedu PiS 27.10.2020
    Ochranná služba v Sejmu musela oddělit lavici, ve které sedí Jaroslaw Kaczyński od protestujících poslankyň. „Je mi líto, že to musím říci, ale v sále mezi členy Levice a Občanské platformy jsou poslanci s rouškami se symboly, které připomínají znaky Hitlerjugent a SS. Chápu však, že totální opozice odkazuje na totalitní vzorce.“ řekl na začátku […]
    Jaromír Piskoř

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