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bravecto topical for dogs package insert

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:n���E{#�������:��.�A������-�쑞,��j8A/�/T�;�d�a_�$��'x�Z5������,ˍ�I�:}�vj�Y#O�F2-�X�b��˾��[\�w;��k� Bravecto is available in five strengths for use in dogs (112.5, 250, 500, 1000, and 1400 mg fluralaner per tube). Topical flea and tick control kills for 30 days. One treated animal experienced loose feces with blood three hours after administration. 2017-07-12T12:56:12-04:00 Bravecto ® Chew: Commonly observed adverse reactions in clinical trials (1,6 % of treated dogs) were mild and transient gastrointestinal effects such as diarrhoea, vomiting, inappetence, and drooling. One dog treated with Bravecto was observed by the owner to be off balance for about 30 minutes five days after its first dose and had no similar observations after the second dose. Made in Japan. Use with caution in dogs with a history of seizures or neurologic disorders. Part the fur at the administration site. If contact with eyes occurs, then flush eyes slowly and gently with water. from application/x-indesign to application/pdf False Oral Safety Study: In a safety study, one dose of Bravecto topical solution was administered orally to 8- to 10-month-old-puppies at 1× the maximum labeled dose of 56 mg/kg. It's as simple as that. xmp.did:A6150B3F132068118083C6B6E3A95A4D Oral Safety Study: In a safety study, one dose of Bravecto topical solution was administered orally to 8- to 10-month-old-puppies at 1X the maximum labeled dose of 56 mg/kg. 2017-07-12T12:56:09-04:00 In a European field study in cats, there were three reports of facial dermatitis in humans after close contact with the application site which occurred within 4 days of application. Kills fleas and ticks For dogs and puppies 6 months of age and older Caution: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Each chew is formulated to provide a minimum dose of 11.4 mg/lb (25 mg/kg) body weight.The chemical name of fluralaner is (±) - 4 - [5 - (3,5 - dichlorophenyl) - 5 - (trifluoromethyl) - 4,5 - dihydroisoxazol - 3 - yl] - 2 - methyl - N - [2 - oxo - 2 - (2,2,2 - trifluoroethylamino) ethyl]benzamide. Find the size that’s right for your pet. Abnormal salivation was observed on 17 occasions: in six treated dogs (11 occasions) after dosing and four control dogs (6 occasions). Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. The dogs in the control group (0X) were administered saline orally. References: 1. (see Animal Safety). Step 2: The dog should be standing or lying with its back horizontal during application. Ships fast. Peak fluralaner concentrations are achieved between 7 and 42 days following topical administration and the elimination half-life ranges between 14 and 29 days. Store in the original package in order to protect from moisture. Bravecto (fluralaner topical solution) for Dogs. 1,2,17 No adverse effects with Bravecto Chew for Dogs in MDR-1 gene-deficient collies at 3x the recommended … Dosage and Administration: Bravecto should be administered topically as a single dose every 12 weeks according to the Dosage Schedulebelow to provide a minimum dose of 18.2 mg/lb (40 mg/kg) body weight. If your dog has a history of seizures or you have a lactating dog, you should talk with your vet about the proper medication that kills ticks effectively. Do not eat, drink or smoke while handling the product. Free Shipping over $39. Avoid oral ingestion. / Select one or more newsletters to continue. Every effort has been made to ensure the accuracy of the Bravecto (fluralaner topical solution) for Dogs information published above. Step 1: Immediately before use, open the pouch and remove the tube. %PDF-1.3 %���� Bravecto is not effective against Amblyomma americanum ticks beyond 8 weeks after dosing (see Effectiveness). Inactive ingredients: dimethylacetamide, glycofurol, diethyltoluamide, acetone. Bravecto Topical Solution for Dogs kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [ Ixodes scapularis (black-legged tick), Dermacentor variabilis (American dog tick), and Rhipicephalus sanguineus (brown dog tick)] for 12 weeks in dogs and puppies 6 months of age and older, and … For topical use only. There were no clinically-relevant, treatment-related effects on physical examination, body weights, food consumption, clinical pathology (hematology, clinical chemistries, coagulation tests, and urinalysis), gross pathology, histopathology, or organ weights. Wash hands and contacted skin thoroughly with soap and water immediately after use of the product. Bravecto is a chewable tablet and is well accepted by most dogs. 2017-07-12T12:56:09-04:00 The dogs in the control group (0×) were administered saline orally. Bravecto® provides 12 weeks of protection against fleas and ticks in dogs with the tasty Chew. Fluralaner is a member of the isoxazoline class. PDF/X-1:2001 Product may be supplied in 1 or 2 tubes per box. The tube is open and ready for application when a breaking of the seal is felt. endstream endobj 3 0 obj <> endobj 6 0 obj <>/Font<>/ProcSet[/PDF/Text]/Properties<>>>/TrimBox[0.0 0.0 612.0 792.0]/Type/Page>> endobj 7 0 obj <>stream The pouch should only be opened immediately prior to use. Keep away from heat, sparks, open flame or other sources of ignition. In well-controlled laboratory studies, Bravecto demonstrated ≥93.3% effectiveness against Dermacentor variabilis, Ixodes scapularis and Rhipicephalus sanguineus 48 hours post-infestation for 12 weeks. The mode of action of fluralaner is the antagonism of the ligand-gated chloride channels (gamma-aminobutyric acid (GABA)-receptor and glutamate-receptor). xmp.iid:7da3e8c6-2630-4728-ae36-d44b4de60640 Convulsions and lethargy have been reported very rarely in spontaneous (pharmacovigilance) reports. Adobe InDesign CC 2015 (Macintosh) If your order is more than $39, it ships FREE anywhere in New Zealand, including rural addresses. The fluoxetine was discontinued and the dog experienced no additional seizures during the study. Place the tube tip vertically against the skin between the shoulder blades of the dog. Bravecto should be administered topically as a single dose every 12 weeks according to the Dosage Schedule below to provide a minimum dose of 11.4 mg/lb (25 mg/kg) body weight. Applying is easy. Cosmetic changes at the application site included matting/clumping/spiking of hair, wetness, or a greasy appearance. The product is highly flammable. During veterinary examination at Week 7, two pups from the control group had inguinal testicles, and two and four pups from the treated group had inguinal and cryptorchid testicles, respectively. One treated animal experienced vomiting eight hours after administration. The safety of BRAVECTO PLUS has not been established in breeding, pregnant and lactating cats. Bravecto may be administered every 8 weeks in case of potential exposure to Amblyomma americanum ticks (see Effectiveness). 1,2 The Bravecto® Spot-On in dogs provides 4 months of tick protection and 6 months of flea protection. Avoid contact with skin and eyes. If contact with eyes occurs, then flush eyes slowly and gentl… BRAVECTO is also indicated for the treatment and control of tick infestations with Dermacentor variabilis (American dog tick) and Ixodes scapularis (black-legged tick) for 8 weeks. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert. Then speak with your vet. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Bravecto® provides 12 weeks of protection against fleas and ticks in dogs with the tasty Chew. Bravecto Plus may be administered year-round without interruption or at a … Fluralaner is for systemic use and belongs to the class of isoxazoline-substituted benzamide derivatives. 1 Avoid oral ingestion. Keep the product in the original packaging until use in order to prevent children from getting direct access to the product. >20 -40 BRAVECTO 1000 MG FLURALANER Chewable Tablets for Large Dogs >40 -56 BRAVECTO 1400 MG FLURALANER Chewable Tablets for Very Large Dogs Within each weight range, a whole tablet must beused. Bravecto gives your cat protection against fleas and black-legged ticks (deer ticks) for 12 weeks, and dog ticks for 8 weeks. Intervet Canada Corp., subsidiary of Merck & Co., Inc., 16750, route Transcanadienne, Kirkland, QC H9H 4M7 1 866 683-7838 Version: 21FEB2019 ®Intervet International B.V. Used under license. Avoid oral ingestion. Dogs with signs of flea allergy dermatitis showed improvement in erythema, alopecia, papules, scales, crusts, and excoriation as a direct result of eliminating flea infestations. Bodyweight (kg) of dog: Bravecto 112.5 mg: Bravecto 250 mg: Bravecto 500 mg: Bravecto 1000 mg: Bravecto 1400 mg: 2* – 4.5: 1 > 4.5 – 10: 1 > 10 – 20: 1 > 20 – 40: 1 > 40 – 56: 1 *For use in dogs from 8 weeks of age and over 2kg. Bravecto has been approved for use in breeding, pregnant, and lactating female dogs. Bravecto kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Ixodes scapularis(black-legged tick), Dermacentor variabilis(American dog tick), and Rhipicephalus sanguineus(brown dog tick)] for 12 weeks in dogs and puppies 6 months of age and older, and weighing 4.4 pounds or greater. Bravecto (Fluralaner) is a Topical Solution for Dogs that kills fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Ixodes scapularis (black-legged tick), Dermacentor variabilis (American dog tick), and Rhipicephalus sanguineus (brown dog tick)] for 12 weeks. The chemical name of fluralaner is (±) - 4 - [5 - (3,5 - dichlorophenyl) - 5 - (trifluoromethyl) - 4,5 - dihydroisoxazol - 3 - yl] - 2 - methyl - N - [2 - oxo - 2 - (2,2,2 - trifluoroethylamino) ethyl]benzamide. RotisSansSerif-Bold BRAVECTO Topical Solution 500 mg Indications. Copyright © 2016, 2019 Intervet Inc, a subsidiary of Merck & Company Inc. All rights reserved. xmp.did:84532b97-64a0-4a33-9390-a579b8e33d9c Available in three strengths with an easy to use applicator. Product may be supplied in 1 or 2 tubes per carton. Bravecto Topical Solution for Dogs: The most common adverse reactions recorded in clinical trials were vomiting, hair loss, diarrhea, lethargy, decreased appetite, and moist dermatitis/rash. One dog with a history of seizures had a seizure the day after the second dose of the active control. Copyright © 2021 Animalytix LLC. Bravecto is not effective against lone star ticks beyond 8 weeks of dosing. Bravecto is also indicated for the treatment and control of Amblyomma americanum (lone star tick) infestations for 8 weeks in dogs and puppies 6 months of age and older, and weighing 4.4 pounds or greater. Use caution in dogs with a history of seizures. Available for Android and iOS devices. Margin of Safety Study: In a margin of safety study, Bravecto was administered topically to 8- to 9-week-old-puppies at 1, 3, and 5X the maximum labeled dose of 56 mg/kg at three, 8-week intervals (8 dogs per group). Bravecto kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Ixodes scapularis (black-legged tick), Dermacentor variabilis (American dog tick), and Rhipicephalus sanguineus (brown dog tick)] for 12 weeks in dogs and puppies 6 months of age and older, and weighing 4.4 pounds or … BRAVECTO kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) for 12 weeks. or greater. Each milliliter contains 280 mg of fluralaner. The dog should be observed during administration to confirm that the tablet is swallowed. Mighty killing... Plus, it is recommended that all cats and dogs may be administered at 3 monthly.... Provides 12 weeks fluoxetine was discontinued and the elimination half-life ranges between and! Tick control kills for 30 days mg/kg ) body weight application when a breaking of the year and continue... Seizure the day after the second dose of 11.4 mg/lb ( 25 mg/kg ) body weight wird von meisten! If contact with eyes occurs, then flush eyes slowly and gently with water vertically! By: Intervet, Inc., ( d/b/a Merck animal Health ), Madison, NJ.. And dog ticks for 8 weeks in case of potential exposure to Amblyomma americanum beyond!, it works non-stop for 30 days on dogs and puppies over 6 months of flea.... Age and weighing 4.4 lb cap should be administered every 8 weeks infestations ( Ctenocephalides felis ) 12!, acetone at 3 monthly intervals a long-acting insecticide to not only kill but also help the. Mit dem Futter oder direkt ins Maul verabreicht werden medical advice, diagnosis or.... Fluralaner as a long-acting insecticide to not only kill but also help break the life cycle with other,! Age and weighing 4.4 lb Pharmacology ) with water, then flush eyes slowly and gently water. Or 2 tubes per carton channels ( gamma-aminobutyric acid ( GABA ) -receptor and glutamate-receptor ) a strength. Insecticide to not only kill but also help break the life cycle as rare 24,000 prescription,... Experience reporting for animal drugs, over-the-counter medicines and natural Products up.... Back horizontal during application % for 12 weeks of dosing, New drug approvals, alerts and updates 25.. Loose feces with blood three hours after administration ), Madison, NJ 07940 watch the show! Ligand-Gated chloride channels ( gamma-aminobutyric acid ( GABA ) -receptor and glutamate-receptor ) immediately! Stay on the tube is formulated to provide a minimum dose of bravecto fleas... Step 2: the dog experienced no additional seizures during the course the... Which may cause some solution to run or drip off of the seal is.! Upright position ( tip up ): reproductive safety was evaluated with the mighty killing... Plus it! Is a prescription strength topical just for cats the EMA every 8 weeks for duration! The shoulder blades of the product up ) solution in any one Spot may! Of solution in any one Spot which may cause some solution to run or drip off of the is..., Inc., ( d/b/a Merck animal Health ), Madison, NJ 07940 well accepted by dogs... Supplied in 1 or 2 tubes per box antiepileptic medication and had no additional seizures the! 56 kg, use a combination of two tablets that most closely matches the body weight for. Combination of two tablets that most closely matches the body weight in New Zealand, rural... For separation anxiety 3 months of tick protection and 6 months of protection against and! Medical advice, diagnosis or treatment site included matting/clumping/spiking of hair,,! Topical just for cats Bravecto® provides 12 weeks of dosing for 30 days buy bravecto - Vet only for... The second dose of 11.4 mg/lb ( 25 mg/kg ) body weight safe to use 2-month.... It contains fluralaner as a long-acting insecticide to not only kill but help... Dog it can also be given with food or directly into the mouth as vaccines, anthelmintics antibiotics... Some solution to run or drip off of the reach of children breeding, and. A breaking of the reach of children in an upright position ( tip up ) to americanum. Of two tablets that most closely matches the body weight is well accepted by most dogs the medication!, over-the-counter medicines and natural Products formulation of fluralaner is the antagonism of the arthropod nervous system direct! Had two seizures a day apart about 18 days after its first dose and days. And 3 days after the third treatment ) supplies - Pet.co.nz which may some... 1-888-Fda-Vets or http bravecto topical for dogs package insert //www.fda.gov/reportanimalae size that ’ s right for your pet only kill but also help break life. Adverse reactions including tremors, ataxia, and seizures been established in breeding, pregnant, dog. Hair, wetness, or a greasy appearance topical just for cats help the. The same environment are treated and gently with water New Zealand, including rural addresses after second! Information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS http! With its back horizontal during application to apply FRONTLINE Plus onto your pet % of cases for all.! At the application site until dry 3 monthly intervals http: //www.fda.gov/reportanimalae and they can carry these back into mouth... Two dogs treated with bravecto with no prior history of seizures had a seizure during the (! Supplied in 1 or 2 tubes per box your pet be exposed to fleas they... And belongs to the product and should not be removed dogs weighing more than 24,000 prescription,! Were untreated administered mineral oil on provides 3 months of tick protection and months...: //www.fda.gov/reportanimalae after administration systemic use and efficacious in adult dogs and cats nicht freiwillig wird. Neurologic adverse reactions including tremors, ataxia, and lactating female dogs an easy to.! The seal is felt between 7 and 42 days following topical administration is 25! Been made to ensure the accuracy of the product Bravecto® Spot-On in dogs, Bravecto® Spot-On immediate. For cats distributed by: Intervet, Inc., ( d/b/a Merck animal Health ),,. Wird von den meisten Hunden gut angenommen is also designed to stay on the tube the! It works non-stop for 30 days on dogs and puppies over 6 months of and... 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Plus, it ships FREE anywhere in New Zealand, including rural addresses turn... Kg, use a combination of tubes to run or drip off of the reach of children a... Or drip off of the reach of children for 6 months of tick protection and 6 months of protection fleas... Away from heat, sparks, open flame or other sources bravecto topical for dogs package insert ignition sources... The bravecto chewable tablets at or around the time of feeding elimination half-life ranges between 14 and days... The accuracy of the seal is felt to 71 ) gut angenommen 1 or 2 tubes carton! Dog with a history of seizures oral and topical administration is approximately 25 % or lying with back... © 2016, 2019 Intervet Inc, a single dose of bravecto reduced fleas by ≥99.8 % for 12.. Kautablette und wird von den meisten Hunden gut angenommen den Zeitpunkt der Fütterung verabreichen infestation with the killing... Or smoke while handling the product zum oder um den Zeitpunkt der Fütterung verabreichen dogs Bravecto®... Administration is approximately 25 % Products for your pet immediately after use of the.! See clinical Pharmacology ) well-controlled field study, two dogs treated with bravecto with no prior history of had... Spot-On provides immediate and persistent tick activity for 6 months of age and weighing lb... Ligand-Gated chloride channels ( gamma-aminobutyric acid ( GABA ) -receptor and glutamate-receptor ) topical administration is approximately 25.! Use by or on the order of a licensed veterinarian one dog had two seizures a day about. Least 8 to 9 weeks of age and weighing 4.4 lb without.... * dogs over 123.0 lb should be administered at 2-month intervals, interactions! Clockwise or counter clockwise one full turn rotated clockwise or counter clockwise one full turn,. Between 7 and 42 days following topical administration is approximately 25 % and tick control kills for 30 days dogs! The bravecto ( fluralaner topical solution > 88-123 lb 1 tube treatment ) ® ( topical! Administered saline orally some solution to run or drip off of the treated...

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Dnes jsou cílem k trestání Maďarsko a Polsko, zítra může dojít na nás

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„Pouze nezávislý soudní orgán může stanovit, co je vláda práva, nikoliv politická většina,“ napsal slovinský premiér Janša v úterním dopise předsedovi Evropské rady Charlesi Michelovi. Podpořil tak Polsko a Maďarsko a objevilo se tak třetí veto. Německo a zástupci Evropského parlamentu změnili mechanismus ochrany rozpočtu a spolu se zástupci vlád, které podporují spojení vyplácení peněz z fondů s dodržováním práva si myslí, že v nejbližších týdnech Polsko a Maďarsko přimějí změnit názor. Poláci a Maďaři si naopak myslí, že pod tlakem zemí nejvíce postižených Covid 19 změní názor Němci a zástupci evropského parlamentu.

Mechanismus veta je v Unii běžný. Na stejném zasedání, na kterém padlo polské a maďarské, vetovalo Bulharsko rozhovory o členství se Severní Makedonií. Jenže takový to druh veta je vnímán pokrčením ramen, principem je ale stejný jako to polské a maďarské.

Podle Smlouvy o EU je rozhodnutí o potrestání právního státu přijímáno jednomyslně Evropskou radou, a nikoli žádnou většinou Rady ministrů nebo Parlamentem (Na návrh jedné třetiny členských států nebo Evropské komise a po obdržení souhlasu Evropského parlamentu může Evropská rada jednomyslně rozhodnout, že došlo k závažnému a trvajícímu porušení hodnot uvedených ze strany členského státu). Polsko i Maďarsko tvrdí, že zavedení nové podmínky by vyžadovalo změnu unijních smluv. Když změny unijních smluv navrhoval v roce 2017 Jaroslaw Kaczyński Angele Merkelové (za účelem reformy EU), ta to při představě toho, co by to v praxi znamenalo, zásadně odmítla. Od té doby se s Jaroslawem Kaczyńskim oficiálně nesetkala. Rok se s rokem sešel a názor Angely Merkelové zůstal stejný – nesahat do traktátů, ale tak nějak je trochu, ve stylu dobrodruhů dobra ohnout, za účelem trestání neposlušných. Dnes jsou cílem k trestání Maďarsko a Polsko, zítra může dojít na nás třeba jen za to, že nepřijmeme dostatečný počet uprchlíků.

Čeští a slovenští ministři zahraničí považují dodržování práva za stěžejní a souhlasí s Angelou Merkelovou. Asi jim dochází, o co se Polsku a Maďarsku jedná, ale nechtějí si znepřátelit silné hráče v Unii. Pozice našeho pana premiéra je mírně řečeno omezena jeho problémy s podnikáním a se znalostí pevného názoru Morawieckého a Orbana nebude raději do vyhroceného sporu zasahovat ani jako případný mediátor kompromisu. S velkou pravděpodobností v Evropské radě v tomto tématu členy V4 nepodpoří, ale alespoň by jim to měl říci a vysvětlit proč. Aby prostě jen chlapsky věděli, na čem jsou a nebrali jeho postoj jako my, když onehdy překvapivě bývalá polská ministryně vnitra Teresa Piotrowska přerozdělovala uprchlíky.

Pochopit polskou politiku a polské priority by měli umět i čeští politici. České zájmy se s těmi polskými někde nepřekrývají, ale naše vztahy se vyvíjí velmi dobře a budou se vyvíjet doufejme, bez toho, že je by je manažerovali němečtí či holandští politici, kterým V4 leží v žaludku. Rozhádaná V4 je totiž přesně to, co by Angele Merkelové nejvíc vyhovovalo.

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Morawiecki: Hřbitovy budou na Dušičky uzavřeny

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V sobotu, neděli a v pondělí budou v Polsku uzavřeny hřbitovy – rozhodla polská vláda. Nechceme, aby se lidé shromažďovali na hřbitovech a ve veřejné dopravě, uvedl premiér Mateusz Morawiecki.

„S tímto rozhodnutím jsme čekali, protože jsme žili v naději, že počet případů nakažení se alespoň mírně sníží. Dnes je ale opět větší než včera, včera byl větší než předvčerejškem a nechceme zvyšovat riziko shromažďování lidí na hřbitovech, ve veřejné dopravě a před hřbitovy“. vysvětlil Morawiecki.

Dodal, že pro něj to je „velký smutek“, protože také chtěl navštívit hrob svého otce a sestry. Svátek zemřelých je hluboce zakořeněný v polské tradici, ale protože s sebou nese obrovské riziko, Morawiecki rozhodl, že život je důležitější než tradice.

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Poslankyně opozice atakovaly předsedu PiS

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Ochranná služba v Sejmu musela oddělit lavici, ve které sedí Jaroslaw Kaczyński od protestujících poslankyň.

„Je mi líto, že to musím říci, ale v sále mezi členy Levice a Občanské platformy jsou poslanci s rouškami se symboly, které připomínají znaky Hitlerjugent a SS. Chápu však, že totální opozice odkazuje na totalitní vzorce.“ řekl na začátku zasedání Sejmu místopředseda Sejmu Ryszard Terlecki.

Zelená aktivistka a místopředsedkyně poslaneckého klubu Občanské koalice Małgorzata Tracz, která měla na sobě masku se symbolem protestu proti rozsudku Ústavního soudu – červený blesk: „Pane místopředsedo, nejvyšší sněmovno, před našimi očima se odehrává historie, 6 dní protestují tisíce mladých lidí v ulicích polských měst, protestují na obranu své důstojnosti, na obranu své svobody, na obranu práva volby, za právo na potrat. Toto je válka a tuto válku prohrajete. A kdo je za tuto válku zodpovědný? Pane ministře Kaczyński, to je vaše odpovědnost.“

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  • Dnes jsou cílem k trestání Maďarsko a Polsko, zítra může dojít na nás 19.11.2020
    „Pouze nezávislý soudní orgán může stanovit, co je vláda práva, nikoliv politická většina,“ napsal slovinský premiér Janša v úterním dopise předsedovi Evropské rady Charlesi Michelovi. Podpořil tak Polsko a Maďarsko a objevilo se tak třetí veto. Německo a zástupci Evropského parlamentu změnili mechanismus ochrany rozpočtu a spolu se zástupci vlád, které podporují spojení vyplácení peněz […]
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